Dr. Suresh Y A

Description:The screening test for diabetes mellitus during pregnancy is done for all the pregnant women by Glucose Challenge Test (GCT) and if raised oral Glucose Tolerance Test ( OGTT) is done. In this study, single elevated 100gm OGTT value associated with effects on the neonate out come like, APGAR Score, large for gestational age & hyperbilirubinemia were studied in 500 pregnant women. GCT was considered high if the glucose level was >140 mg/dl and are considered as positive and OGTT were done with 100 gm glucose. The result of our study suggest that having a positive GCT is an independent risk factor for adverse neonatal outcome like large for gestational age 2.2% in normal GTT group in compared to 10.8% in impaired GTTgroup, and hyperbilirubinemia were significantly high in those patients. Gestational diabetes mellitus is diagnosed by a 2-step method, with a 3-hour, 100-g oral glucose tolerance test that is reserved for women with an abnormal 1-hour, 50-g glucose challenge test. Although the increased maternal-fetal morbidity with gestational diabetes mellitus is well established, controversy remains about the risk that is associated with an isolated abnormal value during a 3-hour, 100-g oral glucose tolerance test [1,2]. The result of Chaturvedi [3] suggest that having a positive GCT is an independent risk factor for adverse perinatal outcome like preeclamsia, post partum hemorrhage, and incidence of ceaserian sections were significantly high in these patients.

Description:Accurate analysis of endometrial sampling and localization of intrauterine lesions is the goal to effective management and better outcome of problem. Histological characteristics of endometrial biopsy material as assessed by light microscopy remains the diagnostic standard for the diagnosis of endometrial pathology. Abnormal uterine bleeding (AUB) is a common condition that patients and gynaecologists encounter. It has a negative impact on women's quality of life and psychologically. It is of particular significance in developing countries since it contributes to anemia's causes. Abnormal uterine bleeding (AUB) management is incomplete without tissue diagnosis, particularly in perimenopausal and postmenopausal women. The diagnosis of endometrial pathology is still based on the histological characteristics of endometrial biopsy material as determined by light microscopy. This was a prospective observational study. A total of 359 women, who are more than 45 years of age with abnormal uterine bleeding, who needed endometrial curettage were included in the study. A significant association was found between pattern of histopathology & hypertension with a p value of <0.01. Hypertension was more common in patients with atrophic endometrium, endometrial hyperplasia and endometrial malignancy with 12 out of 20, 68 out of 96 and 14 out of 23 patients respectively. Majority of the patients 68 out of 116 with hypertension had endometrial hyperplasia. We found a maximum incidence of AUB in multiparous women. Clinicohistopathological analysis of AUB revealed endometrial hyperplasia in majority of patients.